How George Lopez's marriage to ex-wife Ann Serrano unraveled despite donating the comedian her kidney

George Lopez and his ex-wife Ann Serrano were believed to have had one of the strongest marriages in Hollywood before they split in 2010. Over the course of their 17-year union, the pair faced highs and lows including his wife making a life-saving kidney donation after a genetic condition caused the comedian's own kidneys to deteriorate. Despite this, the pair's relationship came to an end five years later - with Ann filing for divorce amid speculation that George had been unfaithful.

The pair's split was finalized in 2011 and both have moved on in that time, though they have remained connected while co-parenting their daughter, Mayan Lopez. The relationship has come to the forefront once again after the comedian made headlines this week thanks to his very disheveled appearance at The Jennifer Hudson Show. The actor - who was heckled by a crowd amid a stand-up show last year - sported long gray hair as well as a scruffy beard for the interview.

As fans reacted to his appearance on X, one user tweeted: 'George Lopez took that lady's kidney and then divorced her. That’s why he look like that. Good.'. Another wrote: 'George Lopez looks awful but he actually deserves to look even more hideous for dumping his wife after she donated her kidney to him.'. George Lopez and ex-wife Ann Serrano were believed to have had one of the strongest marriages in Hollywood before they split in 2010.

The comedian has made headlines this week thanks to his very disheveled appearance as he stopped by The Jennifer Hudson Show. 'George Lopez really out here proving that karma don’t miss,' one user commented. 'Took his wife’s kidney, abandoned her, and now he’s on TV looking like he hasn’t slept since the transplant. Life came collectin’ FAST.'. The resurgence of his past behavior came as a shock to many, as one X user commented: 'Why I’m Just Finding Out That George Lopez Took his Wife kidney then divorced her.'.

Another wrote: 'Today years old when I found out George Lopez’s ex wife donated a kidney to him before they divorced. Once he got better, they split up. George and Ann tied the knot in 1993 and welcomed their daughter Mayan three years later. As a result of a genetic condition that caused his kidneys to deteriorate, George was told by doctors in 2004 that he needed an organ transplant. The comedian had been diagnosed with polycystic kidney disease, a condition that causes cysts to form on the kidneys and eventually leads to kidney failure.

In 2005, the family made headlines when it was revealed that Ann had given George the gift of life by donating one of her kidneys to him. As fans reacted to his appearance on X, his past behavior soon became a hot topic. The end of his marriage after such a big sacrifice from his ex-wife can as a shock to many. Ann told reporters at the time: 'George, he comes from a very dysfunctional family, a horrific childhood. It was hard for him to accept that someone would give him the gift of life.'.

The Lopez Tonight host added: 'I was crying. I thanked her and I told her I loved her. I was more concerned about her than I was about myself.'. He also told People: 'I can’t pay her back, but what I can do is make her as happy as she thought I would when we first got married.'. George later went on to lose 45lbs, crediting the operation with vastly improving his health. However, the pair ended their marriage in November 2010, citing 'irreconcilable differences'.

Both parties claimed the split was amicable and by mutual agreement, with reports at the time saying that they had been working out the details of the split 'for a long time'. In the years since, his daughter Mayan has spoken out about her father's faults and hinted that his actions led to the rift between her parents. Though reports of an affair were never confirmed, she told UsWeekly: 'Him abandoning me in a time after the divorce, and it was really public, and divorce is hard enough, but to have people making opinions about your family even for decades after is not easy on a 15-year-old.'.

In 2005 the former couple made headlines when it was revealed that Ann had given George the gift of life by donating one of her kidneys to him. He also told People at the time: 'I can’t pay her back, but what I can do is make her as happy as she thought I would when we first got married'. The pair's split was finalized in 2011 and both have moved on in that time , though they remained connected while co-parenting their daughter, Mayan Lopez.

In the years since, his daughter Mayan has spoken out about her father's faults and hinted that his actions led to the rift between her parents. George's latest TV appearance quickly became a hot topic online as social media users became more focused on his altered look. One person penned: 'What happened to dude. He was normal looking five years ago.'. Others compared George to the German philosopher and political economist Karl Marx, with one typing, 'He looks like Karl Marx. Long hair is a ridiculous look on anyone over the age of 25.'.