Cairess finished third at the event last year and was hoping to challenge Mo Farah’s British record over the distance.
Cairess clocked the second-fastest time by a British athlete on his way to a third-placed finish at the event last year, and looked set to again lead home hopes.
“I was really looking forward to racing the world’s best marathon runners and to build on the progress I have made over the marathon distance,” the 27-year-old athlete said.
The elite men’s field remains exceptionally strong even with the Briton absent, with Jacob Kiplimo, the new half-marathon world record holder, tipped by many to challenge the 26.2-mile mark in 2025.
Defending champion Alex Mutiso, former world record-holder Eliud Kipchoge and Olympic champion Tamirat Tola are also set to compete on Sunday 27 April.
