England team: M Smith (Harlequins); T Freeman (Northampton), O Lawrence (Bath), H Slade (Exeter), O Sleightholme (Northampton); F Smith (Northampton), A Mitchell (Northampton); E Genge (Bristol), L Cowan-Dickie (Sale), W Stuart (Bath), M Itoje (Saracens), O Chessum (Leicester), T Curry (Sale), B Earl (Saracens), T Willis (Saracens).
It will be Chessum's first start for England since last year's Six Nations having been ruled out of the summer tour to Japan and New Zealand and the autumn series by shoulder and knee injuries.
Chessum will operate alongside Maro Itoje in the second row in a direct swap for George Martin, who has been managing a knee problem and drops to the bench for the Calcutta Cup showdown.
England have made one change for Saturday's Six Nations clash with Scotland at Allianz Stadium by drafting Ollie Chessum into the forwards.
It means England will continue with Marcus Smith at full-back, giving the Harlequins playmaker another run in the unfamiliar position where he mixed good with bad against Les Bleus.