Defending champions Inter, who defeated Genoa 1-0 on Saturday, stay a point clear at the top, while third-placed Atalanta can move to within two points of Napoli with victory at Empoli on Sunday evening.
Ten minutes later, the Napoli forward Giacomo Raspadori pounced on some sloppy defending to slot the ball past the Como keeper, Jean Butez, and level things up.
Napoli could not push on in the second half, and were punished in the 77th minute, when winger Assane Diao fired home a stunning finish from Nico Paz’s precise pass.
Having been overtaken at the summit by Inter on Saturday, Napoli made a nightmare start when Amir Rrahmani gifted the lead to Como in the seventh minute.
Antonio Conte’s side missed the chance to reclaim top spot in Serie A as Assane Diao’s fine strike extended the visitors’ winless streak to four matches.