Scotland: B Kinghorn (Toulouse), K Rowe (Glasgow), H Jones (Glasgow), T Jordan (Glasgow), D Van der Merwe (Edinburgh), F Russell (Bath, co-capt), B White (Toulon); P Schoeman (Edinburgh), D Cherry (Edinburgh), Z Fagerson (Glasgow), J Gray (Bordeaux), G Gilchrist (Edinburgh), J Ritchie (Edinburgh), R Darge (Glasgow, co-capt), J Dempsey (Glasgow).
England: M Smith (Harlequins); T Freeman (Northampton), O Lawrence (Bath), H Slade (Exeter), O Sleightholme (Northampton); F Smith (Northampton), A Mitchell (Northampton); E Genge (Bristol), L Cowan-Dickie (Sale), W Stuart (Bath), M Itoje (Saracens, capt), O Chessum (Leicester), T Curry (Sale), B Earl (Saracens), T Willis (Saracens).
Replacements: E Ashman (Edinburgh), R Sutherland (Glasgow), W Hurd (Leicester), S Skinner (Edinburgh), G Brown (Glasgow), M Fagerson (Glasgow), J Dobie (Glasgow), S McDowall (Glasgow).
Replacements: J George (Saracens), F Baxter (Harlequins), J Heyes (Leicester), T Hill (Bath), C Cunningham-South (Harlequins), B Curry (Sale), H Randall (Bristol), E Daly (Saracens).
The 22-year-old has been at the centre of a saga over the past two months and Exeter made their feelings clear on Thursday with a terse statement that revealed the wing aggravated his shoulder in a rehab session with England during the first rest week of the Six Nations.