), 3 Thomas Clarkson; 4 Joe McCarthy, 5 Tadhg Beirne; 6 Peter O’Mahony, 7 Josh van der Flier, 8 Jack Conan; 9 Jamison Gibson-Park, 10 Sam Prendergast; 11 James Lowe, 12 Robbie Henshaw, 13 Garry Ringrose, 14 Mack Hansen; 15 Jamie Osborne.
On the bench, young Leinster loosehead Jack Boyle is in line for a debut with hooker Gus McCarthy and flanker Cian Prendergast also in line for their first appearances of the campaign.
Sheehan’s elevation from the bench is one of seven alterations made by Simon Easterby for the round three encounter, with the front-rower skippering in the stead of injured No 8 Caelan Doris.
Jack Conan starts in the back row as part of a pack that also includes a fit-again Joe McCarthy at lock and Thomas Clarkson, who is handed a first Test start on the tighthead.
Hooker Dan Sheehan will captain a much-changed Ireland side as the Six Nations favourites bid to continue their grand slam charge against Wales.