Rublev eventually took advantage of Draper's first double fault when he converted the third of three set points to take the first, but having gone the distance in both the last eight and the semi-finals, the Briton dug deep once again to take the second.
The Briton went down 7-5 5-7 6-1 in final to the fifth seed as a concerted fightback eventually came up short in Doha as the 27-year-old Russian claimed the title for a second time.
Jack Draper fell at the final hurdle at the Qatar Open as he was beaten in three sets by Andrey Rublev.
We were exhausted and it was difficult, but somehow we were able to play at a good level.
"When I lost the second set, I let it go and started to play more freely.