Pickford had just tipped a Wissa shot wide, but moments later when Schade’s throw bounced in the Everton penalty area, Bryan Mbeumo’s header came back off the crossbar and Wissa was first to react to nod in the rebound.
Beto, with five goals in his last four league matches, should have scored at least one more before half-time, first when Bees defender Ethan Pinnock slipped as he tried to deal with a long ball.
Mykolenko launched a high cross to the far post where O’Brien lost his marker Paris Maghoma – who had come on as a substitute moments earlier – and dived forward to plant his header past Flekken.
Jake O’Brien’s first Everton goal stretched their unbeaten run to seven Premier League matches after a 1-1 draw at Brentford.
Yoane Wissa’s 13th goal of the season looked set to condemn boss David Moyes to only a second defeat in his eighth league match back in charge.