Perhaps with an eye on the Champions League second leg, Guardiola can rest Kevin De Bruyne, in particular, and hand a Premier League debut to deadline day signing Nico Gonzalez.
Grealish and Akanji both picked up knocks in the first-half of Man City’s Champions League knockout phase playoff first-leg against Real Madrid on Tuesday night.
Manchester City are expected to be without Jack Grealish and Manuel Akanji for Saturday’s Premier League clash at home to Newcastle.
Predicted Man City XI: Ederson; Nunes, Dias, Ake, Gvardiol; Nico, Kovacic; Savinho, Marmoush, Foden; Haaland.
Phil Foden is the most likely candidate having replaced the City no.10 in midweek, though Omar Marmoush will be pushing for a recall and Jeremy Doku could be in contention after being named on the bench last time out.