Finlay Bealham, James Ryan and Bundee Aki move to the replacements while wing Calvin Nash, who was a late injury replacement for Hansen against Scotland in round two, joins Kelleher, Doris and Keenan in dropping out of the matchday squad.
Easterby has made seven changes in personnel for Saturday’s round three showdown, with Dan Sheehan taking over as captain from knee injury victim Caelan Doris.
Uncapped Leinster prop Jack Boyle, 22, is in line for his international debut from a bench also containing Connacht forward Cian Prendergast, the elder brother of Ireland fly-half Sam Prendergast.
Easterby is overseeing Ireland while Andy Farrell prepares for the upcoming British and Irish Lions tour and has so far impressed by masterminding emphatic victories over England and Scotland.
Wales in Cardiff is the next assignment and Easterby, who lives in Swansea and played for and coached the Scarlets, heads to the Principality Stadium amid speculation that he is an option to succeed Gatland.
