With Dominic Solanke (knee) and Richarlison (calf) out, Mathys Tel is expected to lead the line again, while Lucas Bergvall and Rodrigo Bentancur have been Postecoglou’s preferred picks in midfield in the last two games.
With Radu Dragusin (knee), Micky van de Ven (hamstring) and Cristian Romero (thigh) also ruled out, Kevin Danso and Archie Gray will continue in the heart of the Spurs defence.
Predicted Tottenham XI (4-3-3): Vicario; Porro, Danso, Gray, Spence; Bergvall, Bentancur, Maddison; Kulusevski, Son, Tel.
James Maddison was also benched against the Tractor Boys but could come back into midfield against City, with Dejan Kulusevski returning to the right wing.
Tottenham head coach Ange Postecoglou has no fresh injury concerns for the visit of Manchester City on Wednesday but is set to be without Ben Davies again.
