The Eagles' lack of European fixtures would usually be a hindrance but that's irrelevant in Gameweek 25 and so Mateta has to be considered a strong differential given his form of late.
Not only does Mbeumo have the luxury of a rare double Gameweek, he'll kick things off against Leicester on Friday night - only Southampton have conceded more league goals than the Foxes in 2024/25.
Looking further ahead, Oliver Glasner's side have an FA Cup fifth round tie with Millwall in Gameweek 26 - they're one of only three top-flight teams due to face lower-league opposition.
Mitoma has scored four goals in his last six games and will fancy his chances of extending his good form when he meets the top flight's worst defence on Saturday.
Granted, a double header against Bournemouth and Fulham is a tricky proposition this season but Cunha took 12 points off Liverpool last time out, proof he has the ability to cash in against any opponent.
