League leaders Liverpool, meanwhile, have made two changes to the team that beat Manchester City at the weekend, with Diogo Jota and Konstantinos Tsimikas coming in for Curtis Jones and Andy Robertson respectively.
The Newcastle striker has been one of the Premier League’s standout performers this season, netting 19 times in 24 games, with only Mohamed Salah outscoring the Swede in the top flight.
Speaking at his pre-match press conference, Liverpool head coach Slot had been full of praise for Isak, though stressed that Newcastle had dangerous players all over the pitch.
‘Alexander Isak misses out through a slight groin problem this evening,’ Newcastle’s official X account confirmed ahead of kick-off.
Wilson, who came on as a late substitute in Newcastle 4-3 win over Nottingham Forest on Sunday, will be flanked by Anthony Gordon and Jacob Murphy in the visitors’ attack.
