A short statement on Newcastle's official X account stated, "Alexander Isak misses out through a slight groin problem this evening," prior to kickoff.
With 19 goals in 24 appearances this season, the Newcastle striker has been one of the Premier League's most imperious players.
However, Isak, 24, has been pulled out of the Magpies' team for this evening's blockbuster match on Merseyside due to a "slight groin problem.".
ALEXANDER ISAK will not play for Newcastle against Liverpool tonight due to an INJURY.
Against the table-toppers, Wilson, who entered the game as a late replacement in Newcastle's 4-3 victory against Nottingham Forest, will be flanked by Antony Gordon and Jacob Murphy.