Her expletive moment comes just weeks after Zoe crashed the Golden Globes stage during the Best Song award in a bizarre move caught by live TV cameras.
"Zoe Saldana getting on stage during the presentation of Best Song," another said next to a photo of Lil Mama, Jay Z, and Alicia.
The category was ultimately awarded to French musicians Clément Ducol and Camille for their work on the song El Mal for Jacques Audiard's movie Emilia Pérez on Netflix, which Zoe sang for the movie.
Zoe was left emotional as she won Best Supporting Actress for her role in Emilia Pérez, playing Rita Mora Castro, a lawyer who helps a Mexican cartel leader gain access to gender-affirming surgery.
As Clement and Camille were walking up to accept the award, Zoe brazenly rushed on stage and could be seen running in the background.
