The development is a major blow to head coach Ruben Amorim, who revealed ahead of Sunday's trip to Tottenham that they had been hit by some unspecified injuries and illness.
Lisandro Martinez recently sustained a season-ending anterior cruciate ligament injury, while Amorim suggested Luke Shaw, Jonny Evans, Mason Mount and Altay Bayindir remain absent.
Manchester United forward Amad Diallo could miss the rest of the season with ankle ligament damage.
Reports subsequently emerged that United midfielders Kobbie Mainoo, Manuel Ugarte and Toby Collyer picked up injuries in addition to Diallo's setback.
United sit 13th in the Premier League standings ahead of travelling to Tottenham, who are two points behind them.
