A week on from their FA Cup exit, the Blues endured more misery on the south coast, failing to register a single shot on target in a terrible display, one that extends their winless run on the road to six matches.
Kaoru Mitoma gave Brighton the lead in stunning fashion, bringing the ball down with an extraordinary first touch before bending a finish into the bottom corner, and Yankuba Minteh added a second before the break.
Chelsea suffered their second defeat against Brighton in the space of a week as they were beaten 3-0 at the Amex Stadium.