Wednesday's episode will reveal the fates of all four, and will confirm which of them has been confirmed dead by paramedics as shown on Tuesday night.
On Tuesday night it soon became clear that at least four characters faced death, with four different ambulances heading for the hospital.
The four characters in peril were Leyla Harding, Liam Cavanagh, Noah Dingle and Amy.
Taking to social media as Tuesday's episode played out, one fan said: "I think it's Liam that doesn't make it.
Tonight's episode shows some of them getting taken to hospital, the spoilers online show the person dead has a head support brace on.
