Kent Police said in the appeal for information: "A CCTV image of her last known sighting is being issued as part of the appeal and officers are keen to her from anyone who may have seen Alice or knows where she is.
Alice Kent, 13, was last seen at High Brooms railway station in Tunbridge Wells, Kent, on Wednesday morning.
She was wearing a black fluffy coat over a white shirt, a navy blue school skirt, black tights and black loafer shoes.
Officers have also released a CCTV image of Alice from the train station as her search continues.
Anyone that may have information on her whereabouts or think they may have seen her is advised to call 999.