The Metropolitan Police said it is prepared for a “significant policing presence” to halt clashes with counter-demonstrators amid claims by the Palestine Solidarity Campaign (PSC) that hundreds of thousands of people will attend.
The PSC, along with demonstrators from five other groups, will gather in Whitehall at noon before going to the US embassy in Nine Elms Lane, south-west London, where speeches will be made.
A pro-Palestine protest billed by organisers as one of the largest since war broke out between Hamas and Israel will take place in central London on Saturday.
Scotland Yard said a “significant policing presence” is expected to be in place to ensure the groups do not physically come together.
The protest comes after a proposal by President Donald Trump earlier this month for the United States to consider taking ownership of the Gaza Strip.