Pep Guardiola’s side must turn things around after Madrid beat City 3-2 in the first leg last week, staging yet another dramatic late comeback.
While the Premier League champions remain outsiders, confidence is high after City smashed Newcastle 4-0 on Saturday, with January signing Omar Marmoush scoring a hat-trick.
Man City predicted XI: Ederson; Nunes, Dias, Stones, Gvardiol; Gonzalez, Kovacic; Savinho, Foden, Haaland, Marmoush.
Manchester City will hope to have Erling Haaland available for Wednesday’s Champions League showdown against Real Madrid.
Kevin De Bruyne is expected to start after he was rested on Saturday, although all of Manuel Akanji, Rodri and Oscar Bobb are injured for City.