The statement said the redundancies would be part of the club's "transformation plan", adding: "This will create a more solid financial platform from which the club can invest in men's and women's football success and improved infrastructure.
While Sir Jim is the face of the club's ruthless cost-cutting approach, majority owners the Glazers are widely blamed for the malaise and the debt, with many fans accusing them of draining the club of its resources for personal gain since taking it over in 2005.
As well as the redundancies, the plan will see the end of free staff lunches at Old Trafford - saving over £1m per year, according to the club, while staff bonuses will be reduced.
A United statement on Monday revealed that the potential redundancies were aimed at returning the club to profitability after five consecutive years of losses.
The club's CEO Omar Berrada added: "We are initiating a wide-ranging series of measures which will transform and renew the club.
