United beat Leicester 2-1 in the FA Cup last time out and have since been afforded an extended break, although that has not helped Ruben Amorim bolster his options.
Reports suggest that Amad has suffered an ankle injury in training and could miss the rest of the season, in what is a major blow for Amorim.
Kobbie Mainoo, Manuel Ugarte and Toby Collyer are all believed to have picked up issues this week as well, leaving Amorim short of options in midfield.
The United squad have been hit by a sickness bug ahead of the Spurs game, though it remains to be seen how serious an issue that is.
Manchester United will be without Amad Diallo for Sunday’s Premier League trip to Tottenham.
