In the men's World Cup super-G in Crans-Montana, Switzerland, on Saturday, overall World Cup leader and home hero Marco Odermatt took his 45th World Cup victory ahead of compatriot Alexis Monney, while Italian veteran Dominik Paris completed the podium.
Shiffrin won the slalom, finishing 0.61 seconds ahead of second-placed Croatian Zrinka Ljutic, to become the first skier, male or female, to reach triple digits in World Cup race victories.
Shiffrin's hunt for her 100th career World Cup win was put on hold after she crashed during a giant slalom race in Killington, Vermont, in November and suffered a puncture wound in her abdomen.
Less than two months later the twice Olympic gold medallist established herself as the most successful Alpine skier in World Cup history, male or female, when she topped retired Swedish great Ingemar Stenmark's decades-old record of 86 victories.
Shiffrin had appeared slightly off the pace in her World Cup return, finishing 25th in the Sestriere giant slalom on Friday and failing to make the cut in the same category on Saturday.