Full debutant Mathys Tel set up a tense finish with a well-taken volley in the first minute of stoppage-time but Villa held on to leave Spurs’ season hanging on the Europa League.
At fault for the opening goal when Ramsey’s shot went through him but afterwards kept the scoreline respectable with saves to deny Leon Bailey (twice), Morgan Rogers and Ramsey (twice).
Tottenham crashed out of a second cup competition in the space of four days with a 2-1 defeat at Aston Villa in the FA Cup fourth-round, which piled the pressure on head coach Ange Postecoglou.
Looking to respond to Thursday’s 4-0 thrashing by Liverpool in the Carabao Cup, Spurs trailed after 57 seconds when Jacob Ramsey’s fierce shot went through Antonin Kinsky.
But lost possession in the build up to Villa’s second goal and struggled to make any impact for most of the game.