A grey VW Golf and a black Vauxhall Grandland were heading in opposite directions when they collided on Staithes Road, Preston, Hull, at around 1.20am on Wednesday, Humberside Police said.
Two other passengers, a girl aged 16 and a 17-year-old boy, suffered life-threatening injuries and were taken to hospital.
Two teenagers aged 16 and 18 have died following a collision in the early hours of New Year’s Day, police said.
The Vauxhall driver, a woman aged 34, suffered a badly injured arm and they were also taken to hospital.
A 62-year-old man in the Vauxhall Grandland also suffered life-threatening injuries.
