Manchester City, Manchester United, Aston Villa and Newcastle are among the top-flight sides vying for a place in the last eight, with Liverpool and Arsenal having already exited the competition.
Giant-killers Plymouth are looking to go one better as they face City having beaten Liverpool in round four, while Manchester United are trying to salvage something from an embarrassing season as they face Fulham.
The draw will take place after the conclusion of the match between Manchester United and Fulham at Old Trafford on Sunday, 2 March.
On Friday, 28 February, Aston Villa take on Cardiff City, before four ties on Saturday and two on Sunday.
According to the FA’s official website, the quarter-final ties are scheduled to take place over the weekend of Saturday, 29 March.