Saliba has missed Arsenal’s last two games due to a hamstring injury, while Lewis-Skelly was absent for Wednesday’s win over Dinamo Zagreb because of a knee issue.
Ben White, who has been out of action since November after undergoing knee surgery, is progressing well in his recovery but is not quite fit enough to return this weekend.
Arteta is light on options in attack, but both Ethan Nwaneri and Leandro Trossard will be pushing to start after doing well off the bench against Dinamo.
Jurrien Timber was deployed there against Aston Villa last weekend, but on Wednesday for the win over Dinamo, it was Jakub Kiwior who got the nod.
Arteta faces a selection dilemma if Saliba is out of action as to who he plays at centre-back alongside Gabriel.
