Reims beat Ligue 1 rivals Angers 5-3 on penalties after a 1-1 draw to reach the semi-finals of the Coupe de France and fourth tier Cannes upset Ligue 2 side Guingamp 3-1 to reach the last four.
Marius Worl’s curling effort and Bremen defender Julian Malatini’s own goal put Bielefeld 2-0 up and former Scotland winger Oliver Burke pulled one back before the visitors hit the crossbar in time added on through Amos Pieper’s header.
German third tier club Arminia Bielefeld caused another upset in the DFB Pokal by defeating Bundesliga side Werder Bremen 2-1 to reach the last four.
Robert Lewandowski struck the home side’s fourth in the second period, but late goals from Marcos Llorente and Sorloth denied Barca an advantage for the return leg.
Atletico raced into an early lead through Julian Alvarez and Antoine Griezmann before Barca hit back through Pedri, Pau Cubarsi and Inigo Martinez to lead 3-2 at half-time.