One theory claims that it was Kennedy's vice president and presidential successor, Lyndon Johnson, who was so hungry for power that he ordered the hit solely to take the top spot.
The botched military operation put the CIA and Kennedy on rocky terrain, with theorists believing that tension continued to build after the failed assassination attempt against Castro.
According to the official reports, Oswald positioned himself on the sixth floor of the Texas School Book Depository building in downtown Dallas to lay in wait for Kennedy.
Further evidence conspiracy theorists point to include a trip that Oswald made to New Orleans before the killing and the fact that his killer, Jack Ruby, had ties to the mob.
As the motorcade passed by, Oswald let off a volley of rounds, pumping two bullets into the president, one going through his throat and the other through his head.