Dr Krebs says they know that the blood test route "won't work for everyone", but in some cases, it has already enabled patients with advanced cancers to be matched to drug trials.
Dr Matthew Krebs, the study's chief investigator, tells Sky News its research was making "precision medicine" more accessible for a wider range of cancer patients.
Personalised cancer treatment, matched to a patient via a simple blood test, is being hailed as "life-saving", following an initial study.
The Target National study, funded by The Christie Charity and the Sir Bobby Robson Foundation, hopes to recruit 6,000 patients, to examine if the blood-test route, in effect a "liquid biopsy", improves patient outcomes.
The Target National trial, being conducted at The Christie hospital in Manchester, analyses a patient's DNA to determine what type of therapy will work best for them.
