Amanda Pritchard took on the role in 2021, having previously served as NHS England's chief operating officer, and before that, the former head of Guy's and St Thomas' NHS Foundation Trust.
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Her decision to step down comes weeks after MPs on the cross-party Commons health and social care committee accused her of lacking the "drive and dynamism" to radically reform the service.
The head of NHS England is to step down, Sky News understands.
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