It comes weeks after Ms Pritchard and other officials from the Department of Health and Social Care (DHSC) were criticised by MPs for being “complacent” about the scale of change needed to tackle the crisis in the NHS.
NHS England chief executive Amanda Pritchard has announced that she will step down from her role, in a move that is likely to shock the health service.
MPs on the Health and Social Care Committee expressed fears that Ms Pritchard did not have the “drive and dynamism” to transform the NHS.
Sir James Mackey will take over as "transition" chief executive from the first of April, NHS England said in a statement.