Watkins scored his 12th Premier League goal of the season in Wednesday’s 2-2 draw with Liverpool – a game in which January arrivals Rashford and Asensio made their first starts.
Villa gave leaders Liverpool a real test, but their overall inconsistency means they face a tough task to qualify for the Champions League for a second year running.
Watkins added on TNT: “Any team we play, we want to win the game and we will focus on ourselves and see where we are come the end of the season.”.
Makeshift centre-half Boubacar Kamara is also injured so if Ezri Konsa does not come back from a hamstring injury, Lamare Bogarde will be asked to fill in.
Aston Villa striker Ollie Watkins hopes to benefit from the arrival of Marcus Rashford and Marco Asensio.