The outbreak marks the second such incident on the Rotterdam, which witnessed a similar outbreak in December 2024 when 83 passengers and 12 crew were reported ill.
According to the US Centers for Disease Control and Prevention (CDC), the liner currently has 107 sick guests and 12 sick crew members on its current voyage.
The incident comes just days after 90 passengers and crew on a Royal Caribbean cruise in the Gulf of Mexico all fell sick with a similar gastrointestinal illness.
The outbreak was reported to the CDC on 7 February, with more than five per cent of passengers and crew reporting gastrointestinal symptoms.
The US-based health agency classified 2024 as the worst year for stomach illness outbreaks on cruise ships in over a decade as norovirus cases surged in the US.