P&O Cruises has confirmed to Sky News some of its guests "have unfortunately reported gastrointestinal symptoms," however, they said it is currently affecting fewer than 1% of the passengers on board.
One passenger on the P&O Iona told Sky News "people have been dropping like flies", with "a large number" of guests and staff experiencing symptoms.
"We are aware that some guests have unfortunately reported gastrointestinal symptoms recently on board Iona's Northern Europe cruise," P&O Cruises said in a statement.
P&O Cruises told Sky News any symptomatic guests who were unable to join shore experiences will receive a full refund.
The P&O Iona, which can carry more than 5,000 passengers and 1,800 staff, is currently on a seven-day cruise across northern Europe, visiting Hamburg, Rotterdam and Zeebrugge.