Richard Meddings, chairman of NHS England, also described it as "a huge loss" for the NHS, adding: "Under her leadership, the NHS has delivered a huge amount for patients - in the face of pandemic recovery, unprecedented strikes and consecutive even busier winter periods, the NHS has continued to improve performance, reform and innovate.
Prior to that, she had a long history in both medicine and politics, having worked as NHS England's chief operating officer, head of Guy's and St Thomas' NHS Trust in London, and an adviser in Tony Blair's government.
"Amanda can be enormously proud of the leadership she has given in the face of the biggest health emergency for our country in modern history, as well as steering NHS England during turbulent political waters and six secretaries of state in her time as chief executive,” he said.
Sir James Mackey, the current chief executive of Newcastle Hospitals, will take over as interim head of NHS England, the NHS has confirmed.
She has worked in the NHS throughout her entire career and was long expected to step into the role of NHS CEO, before she finally moved from deputy to chief in 2021.
