Gavin Isaacs joined Entain from online gaming content developer Games Global in July last year, seven months after his predecessor Jette Nygaard-Andersen quit following just two years with the group.
Entain has also cashed in on beating UK sports punters, while the group last week predicted a record numbers of Britons would have a flutter on last week's Super Bowl in New Orleans.
But Entain shares have added almost 7 per cent since the beginning of the year as investors have welcomed expectations that BetMGM will finally turn a profit this year.
Entain told shareholders on Tuesday that non-executive chair Stella David would return as interim chief executive while a replacement is found, having held the role in the months prior to Isaacs' appointment.
Interim boss David said Entain is making 'strong progress in delivering our strategic priorities', and reconfirmed expectations that full-year earnings before nasties would come in at the top-end of a £1.04billion to £1.09billion guidance range.
