Scotland have won the last four Six Nations meetings against the Auld Enemy, including a 30-21 victory at Murrayfield last year.
England’s third game of the 2025 Six Nations Championship will see them face Scotland at Twickenham.
Also on the schedule for the third weekend of the Six Nations is Wales v Ireland at 2.15pm on the Saturday and Italy v France at 3pm on Sunday.
England v Scotland, Six Nations 2025: What time is kick-off and what TV channel is it on?
A total of 142 Test matches have been played between the nations since 1871, with England winning 76 and Scotland emerging victorious in 47.
